Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ESRRG | P62508 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20981238 | 0.89 | HTT (0.73) | LTA4HHTTEGFRKDM4EALDH1A1 | |
| SCHEMBL20981242 | 0.88 | HTT (0.71) | LTA4HHTTEGFRKDM4EALDH1A1 | |
| SCHEMBL1241355 | 0.86 | LTA4H (0.64) | LTA4HHTTEGFRKDM4EALDH1A1 | |
| SCHEMBL22151427 | 0.84 | LTA4H (0.79) | LTA4HHTTEGFRESRRGKDM4E | |
| SCHEMBL9199244 | 0.83 | KCNH2 (0.63) | LTA4HKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL51012 | 0.81 | KMT2A (0.71) | ALDH1A1MAPTTDP1RAB9AMEN1 | |
| SCHEMBL1241370 | 0.81 | BCHE (0.64) | LTA4HHTTEGFRKDM4EALDH1A1 | |
| SCHEMBL18891134 | 0.80 | MEN1 (0.55) | LTA4HKDM4EALDH1A1TDP1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL23247221 | 0.79 | KDM4E (0.69) | LTA4HESRRGKDM4EALDH1A1MAPT | |
| SCHEMBL944328 | 0.79 | ITGB3 (0.57) | ITGB3ITGA2BTDP1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136202-A2 | COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2018-07-26 | — | — | WO | disclosed |