Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 7/20 | 0.56 |
| ▸ | CLK2 | P49760 | 13/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 13/20 | 0.56 |
| ▸ | CLK3 | P49761 | 12/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20412335 | 0.93 | CLK2 (0.58) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL20991375 | 0.92 | CLK2 (0.60) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL20466192 | 0.92 | CLK2 (0.55) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL18441206 | 0.90 | CLK2 (0.67) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL18441802 | 0.88 | CLK2 (0.70) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL18441595 | 0.87 | CLK2 (0.69) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL18441848 | 0.87 | WNT1 (0.60) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL20412334 | 0.87 | CLK2 (0.56) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL18441601 | 0.86 | WNT1 (0.57) | WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL18441579 | 0.86 | CLK2 (0.63) | WNT1CLK2DYRK1ACLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350199-B2 | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof | SAMUMED, LLC (US) | 2019-07-16 | — | — | US | disclosed |
| US-20180207141-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350199-B2 | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof | WNT1, WNT3, WNT3A | WNT1 1/4885CLK2 779/4885DYRK1A 513/4885 |
| US-20180207141-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | WNT1, WNT3, WNT3A | WNT1 1/4885CLK2 779/4885DYRK1A 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.