Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.30 |
| ▸ | NPY2R | P49146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19237046 | 1.00 | GAA (0.39) | GAATLR8LMNATP53NR1I2 | |
| SCHEMBL19544072 | 1.00 | GAA (0.39) | GAATLR8LMNATP53NR1I2 | |
| SCHEMBL20633873 | 1.00 | GAA (0.39) | GAATLR8LMNATP53NR1I2 | |
| SCHEMBL23172216 | 0.98 | GAA (0.38) | GAATLR8LMNATP53DNM1 | |
| SCHEMBL26787995 | 0.98 | GAA (0.38) | GAATLR8LMNATP53DNM1 | |
| SCHEMBL22350121 | 0.97 | GAA (0.37) | GAATLR8TP53 | |
| SCHEMBL23219668 | 0.93 | GAA (0.37) | GAATLR8TP53NR1I2 | |
| SCHEMBL22597187 | 0.84 | GAA (0.38) | GAATLR8LMNATP53 | |
| SCHEMBL23082899 | 0.84 | GAA (0.38) | GAATLR8LMNATP53 | |
| SCHEMBL23545042 | 0.83 | LMNA (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530204-B2 | Biocatalytic synthesis of cryptophycin anticancer agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210094942-A1 | BIOCATALYTIC SYNTHESIS OF CRYPTOPHYCIN ANTICANCER AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2021-04-01 | — | — | US | disclosed |
| US-10287267-B2 | Isoquinolin-3-yl carboxamides and preparation and use thereof | SAMUMED, LLC (US) | 2019-05-14 | — | — | US | disclosed |
| US-20180208580-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287267-B2 | Isoquinolin-3-yl carboxamides and preparation and use thereof | DYRK1A, DYRK3, DYRK1B | GAA 3825/4885TLR8 1958/4885LMNA 3767/4885 |
| US-20210094942-A1 | BIOCATALYTIC SYNTHESIS OF CRYPTOPHYCIN ANTICANCER AGENTS | HCCS, ERG28, COASY | GAA 396/4885TLR8 4028/4885LMNA 3854/4885 |
| US-20180208580-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | DYRK1A, DYRK3, DYRK1B | GAA 3825/4885TLR8 1958/4885LMNA 3767/4885 |
| US-11530204-B2 | Biocatalytic synthesis of cryptophycin anticancer agents | HCCS, ERG28, COASY | GAA 396/4885TLR8 4028/4885LMNA 3854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.