⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21019700 | 0.73 | MGLL (0.42) | — | |
| SCHEMBL22214505 | 0.71 | — | — | |
| SCHEMBL12936649 | 0.69 | — | — | |
| SCHEMBL18594707 | 0.69 | — | — | |
| SCHEMBL18594686 | 0.65 | MGLL (0.36) | — | |
| SCHEMBL22223456 | 0.63 | DDAH1 (0.35) | — | |
| SCHEMBL18522924 | 0.62 | — | — | |
| SCHEMBL16104380 | 0.62 | — | — | |
| SCHEMBL18594671 | 0.61 | GSK3A (0.32) | — | |
| SCHEMBL157324 | 0.60 | MGLL (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240216521-A1 | METHODS OF PREPARING CELL-BINDING AGENT-DRUG CONJUGATES | IMMUNOGEN INC (US) | 2024-07-04 | — | — | US | disclosed |
| US-20240207412-A1 | DIELS-ALDER CONJUGATION METHODS | REGENERON PHARMACEUTICALS, INC. (US) | 2024-06-27 | — | — | US | disclosed |
| US-11833214-B2 | Methods of preparing cell-binding agent-drug conjugates | IMMUNOGEN, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-11701427-B2 | Diels-alder conjugation methods | REGENERON PHARMACEUTICALS, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11572349-B2 | Selective sulfonation of benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2023-02-07 | — | — | US | disclosed |
| US-20210101871-A1 | SELECTIVE SULFONATION OF BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. (US) | 2021-04-08 | — | — | US | disclosed |
| US-10912841-B2 | Antibody-drug-conjugate and its use for the treatment of cancer | PIERRE FABRE MEDICAMENT (FR) | 2021-02-09 | — | — | US | disclosed |
| US-20200405874-A1 | METHODS OF PREPARING CELL-BINDING AGENT-DRUG CONJUGATES | IMMUNOGEN, INC. | 2020-12-31 | — | — | US | disclosed |
| US-10822313-B2 | Selective sulfonation of benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200157056-A1 | SELECTIVE SULFONATION OF BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2020-05-21 | — | — | US | disclosed |
| US-20190315699-A1 | SELECTIVE SULFONATION OF BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2019-10-17 | — | — | US | disclosed |
| CN-105944120-B | A kind of folic acid liposome and its preparation method and application being loaded with ten diborane maleimide propionyl piperazines, seven methine cyanines thioether salt | 煦普生物技术（珠海）有限公司 | 2019-08-30 | — | — | CN | disclosed |
| US-10287256-B2 | Selective sulfonation of benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2019-05-14 | — | — | US | disclosed |
| CN-106008578-B | Seven methine cyanines thioether salt of a kind of ten diborane maleimide propionyl piperazine and its preparation method and application | 煦普生物技术（珠海）有限公司 | 2019-01-22 | — | — | CN | disclosed |
| US-20180208562-A1 | Selective Sulfonation of Benzodiazepine Derivatives | IMMUNOGEN, INC. | 2018-07-26 | — | — | US | disclosed |