Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 17/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28123348 | 0.80 | TLR8 (0.49) | TLR8TLR7DHFR | |
| SCHEMBL15305985 | 0.77 | DHFR (0.47) | TLR8TLR7DHFR | |
| SCHEMBL28909381 | 0.75 | DHFR (0.54) | TLR8TLR7DHFR | |
| SCHEMBL28526953 | 0.75 | DHFR (0.54) | TLR8TLR7DHFR | |
| SCHEMBL17545030 | 0.74 | DHFR (0.54) | TLR8TLR7DHFR | |
| SCHEMBL12352102 | 0.72 | DHFR (0.46) | TLR8TLR7DHFR | |
| SCHEMBL9499496 | 0.72 | TLR8 (0.60) | TLR8TLR7DHFR | |
| SCHEMBL2852499 | 0.71 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL13304569 | 0.71 | TLR8 (0.48) | TLR8TLR7 | |
| SCHEMBL20434278 | 0.70 | TLR8 (0.97) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662161-B2 | Pyrimidines and uses thereof | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-05-26 | — | — | US | disclosed |
| US-10662161-B2 | Pyrimidines and uses thereof | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-05-26 | — | — | US | disclosed |
| US-20180215720-A1 | PYRIMIDINES AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-08-02 | — | — | US | disclosed |
| US-20180215720-A1 | PYRIMIDINES AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-08-02 | — | — | US | disclosed |
| US-20180215720-A1 | PYRIMIDINES AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662161-B2 | Pyrimidines and uses thereof | TYMS, DPYD, TYMP | TLR8 1078/4885TLR7 445/4885DHFR 5/4885 |
| US-20180215720-A1 | PYRIMIDINES AND USES THEREOF | TYMS, DPYD, TYMP | TLR8 1078/4885TLR7 445/4885DHFR 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.