Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 4/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27610832 | 0.88 | KMT2A (0.39) | ALDH1A1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL19999169 | 0.82 | KMT2A (0.41) | ALDH1A1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL246709 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL8458747 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL4600933 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3795231 | 0.79 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL21599112 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL9561301 | 0.78 | KMT2A (0.47) | ALDH1A1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL5246333 | 0.77 | KMT2A (0.50) | ALDH1A1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL27625620 | 0.77 | KMT2A (0.46) | ALDH1A1HPGDKDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761026-A | Compositions and methods for in vivo synthesis of non-native polypeptides | 斯克利普斯研究所 | 2022-07-15 | — | — | CN | disclosed |
| EP-3938051-A1 | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF | Aileron Therapeutics, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2021072167-A1 | COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2020190742-A1 | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF | AILERON THERAPEUTICS, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
| WO-2018140799-A2 | NEUROTROPHIN MUTANTS AND USE THEREOF FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS | HORACIO URI SARAGOVI (CA) | 2018-08-02 | — | — | WO | disclosed |