Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29734756 | 0.82 | JAK2 (0.33) | SLC9A1KEAP1JAK2BTK | |
| SCHEMBL26921408 | 0.82 | JAK2 (0.33) | SLC9A1KEAP1JAK2BTK | |
| SCHEMBL21713611 | 0.76 | HCAR3 (0.33) | HCAR3KEAP1NFE2L2 | |
| SCHEMBL20439751 | 0.73 | GRM2 (0.53) | GRM2SLC9A1HCAR3KEAP1NFE2L2 | |
| SCHEMBL29442748 | 0.70 | GRM2 (0.63) | GRM2SLC9A1HCAR3 | |
| SCHEMBL16831208 | 0.70 | GRM2 (0.63) | GRM2SLC9A1HCAR3 | |
| SCHEMBL12703333 | 0.70 | LPL (0.42) | LPLLIPGJAK2BTK | |
| SCHEMBL20269082 | 0.70 | GRM2 (0.46) | GRM2SLC9A1HCAR3KEAP1NFE2L2 | |
| SCHEMBL26921750 | 0.69 | JAK2 (0.33) | JAK2BTK | |
| SCHEMBL29982736 | 0.68 | GRM2 (0.47) | GRM2SLC9A1HCAR3KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |