Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16046368 | 0.87 | CYP2A6 (0.42) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL16047859 | 0.82 | HPGD (0.46) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL16047858 | 0.82 | HPGD (0.46) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL16046587 | 0.74 | KDM4D (0.50) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL11545191 | 0.67 | HAVCR2 (0.43) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7135462 | 0.66 | ALDH1A1 (0.51) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL13943613 | 0.66 | ADORA3 (0.46) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL29956181 | 0.65 | CYP1A2 (0.64) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL13759052 | 0.60 | CYP2A6 (0.64) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL9217948 | 0.60 | ALDH1A1 (0.62) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | GENENTECH, INC. (US) | 2018-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | KDM5A, KDM5C, KDM5B | ALDH1A1 1424/4885ADORA3 3374/4885ADORA2A 3367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.