Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 5/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16660870 | 0.88 | CASP3 (0.45) | CASP3SENP8SENP7SENP6RXFP1 | |
| SCHEMBL10556612 | 0.80 | KDM4E (0.46) | NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7160091 | 0.78 | PRMT5 (0.51) | MAOB | |
| SCHEMBL13151414 | 0.75 | CASP3 (0.57) | CASP3SENP8SENP7SENP6RXFP1 | |
| SCHEMBL8019903 | 0.74 | CASP3 (0.64) | CASP3SENP8SENP7SENP6RXFP1 | |
| SCHEMBL9936494 | 0.72 | DGAT1 (0.69) | CASP3SENP8SENP7SENP6DGAT1 | |
| SCHEMBL20169341 | 0.72 | DGAT1 (0.55) | CASP3SENP8SENP7SENP6DGAT1 | |
| SCHEMBL8007163 | 0.72 | CASP3 (0.56) | CASP3SENP8SENP7SENP6RXFP1 | |
| SCHEMBL18552826 | 0.71 | KDM4E (0.48) | CASP3SENP8SENP7SENP6RXFP1 | |
| SCHEMBL10558967 | 0.71 | PRMT5 (0.50) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862856-B1 | IMIDAZOLE AND TRIAZOLE COMPOUNDS AS DGAT-1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-08-01 | — | — | EP | disclosed |