Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 11/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3891303 | 0.96 | HAO1 (0.61) | HAO1GSK3BPTPN1HDAC8HDAC6 | |
| SCHEMBL2550435 | 0.95 | HAO1 (0.64) | HAO1GSK3BPTPN1HDAC8HDAC6 | |
| SCHEMBL17873432 | 0.92 | GSK3B (0.55) | HAO1GSK3BPTPN1HDAC8HDAC6 | |
| SCHEMBL4331872 | 0.86 | GSK3B (0.48) | HAO1GSK3BPTPN1HDAC8HDAC6 | |
| SCHEMBL2445745 | 0.83 | GSK3B (0.46) | HAO1GSK3BPTPN1HDAC8HDAC6 | |
| SCHEMBL12302179 | 0.82 | GSK3B (0.47) | HAO1GSK3BPTPN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17968936 | 0.82 | CYP2C9 (0.52) | HAO1GSK3BPTPN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17834413 | 0.82 | CYP2C9 (0.52) | HAO1GSK3BPTPN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4943332 | 0.80 | DGAT1 (0.54) | — | |
| SCHEMBL14601431 | 0.80 | HRH3 (0.59) | HAO1PTPN1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862856-B1 | IMIDAZOLE AND TRIAZOLE COMPOUNDS AS DGAT-1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-08-01 | — | — | EP | disclosed |