Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.48 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17873432 | 0.89 | GSK3B (0.55) | GSK3BPTPN1HAO1HDAC1HDAC8 | |
| SCHEMBL3891303 | 0.86 | HAO1 (0.61) | GSK3BPTPN1HAO1HDAC1HDAC8 | |
| SCHEMBL20428558 | 0.86 | HAO1 (0.57) | GSK3BPTPN1HAO1HDAC1HDAC8 | |
| SCHEMBL2550435 | 0.84 | HAO1 (0.64) | GSK3BPTPN1HAO1HDAC1HDAC8 | |
| SCHEMBL2445745 | 0.80 | GSK3B (0.46) | GSK3BPTPN1HAO1HDAC1HDAC8 | |
| SCHEMBL17834413 | 0.79 | CYP2C9 (0.52) | GSK3BPTPN1HAO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12302179 | 0.79 | GSK3B (0.47) | GSK3BPTPN1HAO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17968936 | 0.79 | CYP2C9 (0.52) | GSK3BPTPN1HAO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4943332 | 0.78 | DGAT1 (0.54) | — | |
| SCHEMBL4329859 | 0.76 | ALDH1A1 (0.49) | GSK3BPTPN1HAO1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | disclosed |