Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 6/20 | 0.39 |
| ▸ | UTRN | P46939 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20431130 | 0.79 | NOTUM (0.39) | NOTUMKIF11KITUTRNGPR55 | |
| SCHEMBL20431105 | 0.78 | NOTUM (0.38) | NOTUMKIF11KITUTRNGPR55 | |
| SCHEMBL20879927 | 0.77 | MAPK13 (0.39) | NOTUMCFTRPDE4DNR1I2ADORA3 | |
| SCHEMBL16482021 | 0.73 | L3MBTL1 (0.54) | NOTUMKIF11GPR55POLQ | |
| SCHEMBL20431121 | 0.72 | PTGS2 (0.51) | NOTUMKIF11SCN9A | |
| SCHEMBL18003942 | 0.71 | NOTUM (0.50) | NOTUMKIF11KITUTRNGPR55 | |
| SCHEMBL22628907 | 0.70 | NOTUM (0.49) | NOTUMKIF11UTRNGPR55ADORA3 | |
| SCHEMBL12922485 | 0.70 | CSNK1A1 (0.47) | NOTUMKIF11KITUTRNGPR55 | |
| SCHEMBL5544700 | 0.70 | PTGS2 (0.54) | — | |
| SCHEMBL22163080 | 0.69 | KIF11 (0.58) | NOTUMKIF11UTRNGPR55SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2967073-B9 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-2967073-B1 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-08-01 | — | — | EP | disclosed |