Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22693914 | 0.81 | CA2 (0.50) | CA2CA4MAPTHPGDHSD17B10 | |
| SCHEMBL18593938 | 0.74 | ACHE (0.52) | MAPTHPGDL3MBTL1HTTHTR2A | |
| SCHEMBL2398559 | 0.73 | CA2 (0.58) | CA2CA4MAPTHPGDHSD17B10 | |
| SCHEMBL1119927 | 0.72 | CA2 (0.56) | CA2CA4MAPTHPGDHSD17B10 | |
| SCHEMBL301662 | 0.72 | HSD17B10 (0.59) | CA2CA4MAPTHPGDHSD17B10 | |
| SCHEMBL7213113 | 0.71 | CA2 (0.50) | CA2CA4MAPTHSD17B10POLB | |
| SCHEMBL3683983 | 0.70 | CA2 (0.54) | CA2CA4MAPTHPGDHSD17B10 | |
| SCHEMBL28647762 | 0.69 | CA2 (0.75) | CA2CA4MAPTHPGDHSD17B10 | |
| SCHEMBL23183135 | 0.69 | ALDH1A1 (0.58) | CA2CA1NQO2TTRTUBB4A | |
| SCHEMBL1163205 | 0.69 | CA2 (0.52) | CA2CA4MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4400172-A2 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2024-07-17 | — | — | EP | disclosed |
| EP-3354652-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2018-08-01 | — | — | EP | disclosed |