Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HAT1 | O14929 | 2/20 | 0.44 |
| ▸ | EP300 | Q09472 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20436338 | 0.89 | RAB9A (0.69) | NR4A2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL23612416 | 0.82 | MAPT (0.44) | NR4A2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL26002272 | 0.78 | NR4A2 (0.58) | NR4A2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL2659416 | 0.78 | NR4A2 (0.71) | NR4A2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL28703138 | 0.77 | NR4A2 (0.57) | NR4A2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL17032685 | 0.77 | NR4A2 (0.69) | NR4A2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL16205922 | 0.75 | NR4A2 (0.67) | NR4A2RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL1558890 | 0.74 | NR4A2 (0.65) | NR4A2RAB9ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL23612425 | 0.74 | LMNA (0.47) | RAB9ALMNAALDH1A1MAPTMITF | |
| SCHEMBL20424866 | 0.73 | ALDH1A1 (0.49) | RAB9ALMNAALDH1A1MAPTMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573960-B1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2023-08-16 | — | — | EP | disclosed |
| WO-2018138362-A1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |