Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30401467 | 0.90 | GPR55 (0.53) | GPR55MEN1KMT2AKDRTEK | |
| SCHEMBL20401454 | 0.90 | GPR55 (0.53) | GPR55MEN1KMT2AKDRTEK | |
| SCHEMBL20436386 | 0.89 | ADORA2A (0.55) | GPR55MEN1KMT2AADORA2AADORA2B | |
| SCHEMBL20436401 | 0.87 | ADORA2A (0.47) | ADORA2AADORA2BADORA1TLR8 | |
| SCHEMBL20436694 | 0.87 | ADORA2A (0.50) | MEN1KMT2AADORA2AADORA2BADORA1 | |
| SCHEMBL20436398 | 0.86 | ADORA2A (0.50) | KDRTEKADORA2AADORA2BADORA1 | |
| SCHEMBL20436404 | 0.86 | ADORA2A (0.48) | ADORA2AADORA2BADORA1 | |
| SCHEMBL20436405 | 0.86 | ADORA2A (0.46) | GPR55ADORA2AADORA2BADORA1CTSS | |
| SCHEMBL20436400 | 0.85 | ADORA2A (0.47) | KDRTEKADORA2AADORA2BADORA1 | |
| SCHEMBL20436399 | 0.84 | ADORA2A (0.49) | GPR55ADORA2AADORA2BADORA1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ADORA2A, ADORA2B, ADORA1 | GPR55 170/4885MEN1 3139/4885KMT2A 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.