Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165129 | 0.76 | ALDH1A1 (0.38) | — | |
| SCHEMBL31610616 | 0.76 | PIK3C3 (0.35) | PIK3C3KIF11GRM4 | |
| SCHEMBL2053635 | 0.73 | NOS3 (0.35) | KIF11 | |
| SCHEMBL2039390 | 0.72 | PARP1 (0.30) | — | |
| SCHEMBL2036928 | 0.72 | CHRM2 (0.43) | — | |
| SCHEMBL12482758 | 0.72 | MAPK1 (0.36) | PIK3C3KIF11 | |
| SCHEMBL2037374 | 0.69 | CHRM2 (0.40) | — | |
| SCHEMBL27858991 | 0.68 | PIK3C3 (0.32) | PIK3C3KIF11 | |
| SCHEMBL2035875 | 0.68 | KDM4E (0.40) | — | |
| SCHEMBL29539147 | 0.68 | KIF11 (0.42) | PIK3C3KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |