Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.55 |
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | IDO1 | P14902 | 7/20 | 0.43 |
| ▸ | TDO2 | P48775 | 3/20 | 0.43 |
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21437262 | 0.79 | NOS1 (0.44) | NOS1AXLIDO1METAP2CCNA2 | |
| SCHEMBL767109 | 0.76 | NOS1 (0.55) | NOS1AXLIDO1TDO2METAP2 | |
| SCHEMBL12821601 | 0.76 | NOS1 (0.55) | NOS1AXLIDO1TDO2METAP2 | |
| SCHEMBL767506 | 0.76 | NOS1 (0.55) | NOS1AXLIDO1TDO2METAP2 | |
| SCHEMBL5413400 | 0.76 | NOS1 (0.50) | NOS1AXLIDO1TDO2METAP2 | |
| SCHEMBL767674 | 0.76 | NOS1 (0.55) | NOS1AXLIDO1TDO2METAP2 | |
| SCHEMBL12321248 | 0.75 | NOS1 (0.56) | NOS1AXLIDO1TDO2METAP2 | |
| SCHEMBL6923181 | 0.74 | NOS1 (0.49) | NOS1AXLIDO1TDO2METAP2 | |
| SCHEMBL21196087 | 0.72 | TRPA1 (0.41) | NOS1AXLIDO1CCNA2CDK2 | |
| SCHEMBL1141845 | 0.72 | NOS1 (0.50) | NOS1AXLIDO1TDO2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018138739-A1 | NOVEL ANTIESTROGENIC HETEROCYCLIC COMPOUNDS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2018-08-02 | — | — | WO | disclosed |