SCHEMBL6923181

SCHEMBL6923181

O=C(O)c1c(Br)ccc2[nH]ncc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 5/20 0.49
AXL P30530 1/20 0.49
CCNA2 P20248 1/20 0.42
CDK2 P24941 1/20 0.42
CCNA1 P78396 1/20 0.42
IDO1 P14902 4/20 0.39
TDO2 P48775 2/20 0.39
METAP2 P50579 2/20 0.38
CASP6 P55212 1/20 0.37
CSNK2A1 P68400 1/20 0.37
HCAR2 Q8TDS4 1/20 0.36
PTPN6 P29350 1/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
ALDH1A1 P00352 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL543204 0.81 NOS1 (0.44) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL8062076 0.81 CCNA2 (0.43) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL21793858 0.79 CCNA2 (0.42) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL29705820 0.79 NOS1 (0.49) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL5446861 0.79 CCNA2 (0.42) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL25286660 0.76 NOS1 (0.44) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL23919008 0.76 DHPS (0.42) AXLCCNA2CDK2CCNA1IDO1
SCHEMBL27767951 0.76 NOS1 (0.45) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL20439372 0.74 NOS1 (0.55) NOS1AXLCCNA2CDK2CCNA1
SCHEMBL12321248 0.74 NOS1 (0.56) NOS1AXLCCNA2CDK2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2098513-A1 TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2009-09-09 EP disclosed
WO-2004073612-A2 ESTROGEN RECEPTOR MODULATORS MERCK & CO. INC. (US) 2004-09-02 WO disclosed