Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | YAP1 | P46937 | 3/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 3/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20439391 | 1.00 | RXRA (0.39) | RXRARXRBRXRGMMP1MAPK1 | |
| SCHEMBL20439440 | 0.88 | CYP4F2 (0.40) | RXRARXRBRXRGMAPK1CYP4F2 | |
| SCHEMBL20439439 | 0.84 | CYP4F2 (0.41) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL20439435 | 0.77 | BCL2 (0.44) | YAP1PTPN1 | |
| SCHEMBL5354486 | 0.77 | BCL2 (0.44) | YAP1PTPN1 | |
| SCHEMBL680099 | 0.77 | RXRA (0.49) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL20439315 | 0.73 | PTPN1 (0.41) | YAP1PTPN1 | |
| SCHEMBL680637 | 0.73 | RXRA (0.46) | RXRARXRBRXRGMAPK1CYP4F2 | |
| SCHEMBL20439384 | 0.72 | PTPN1 (0.43) | MAPK1PTPN1 | |
| SCHEMBL28680571 | 0.69 | SCN9A (0.41) | RXRARXRBRXRGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018138739-A1 | NOVEL ANTIESTROGENIC HETEROCYCLIC COMPOUNDS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2018-08-02 | — | — | WO | disclosed |