Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20439976 | 0.85 | POLB (0.50) | PTGS1MEN1KMT2APTGDR2ALDH1A1 | |
| SCHEMBL20439645 | 0.79 | PTGS2 (0.45) | PTGS1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL20425836 | 0.75 | HPGD (0.48) | PTGS1RAB9AMEN1KMT2APTGDR2 | |
| SCHEMBL10211721 | 0.74 | HPGD (0.56) | MEN1KMT2APTGDR2ALDH1A1HPGD | |
| SCHEMBL3159784 | 0.72 | CARM1 (0.57) | PTGS1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL30277860 | 0.71 | HPGD (0.73) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4279383 | 0.71 | HPGD (0.73) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL23979102 | 0.70 | ITGB2 (0.58) | HDAC6 | |
| SCHEMBL3163275 | 0.70 | HPGD (0.53) | PTGS1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL14591322 | 0.70 | PTGDR2 (0.58) | MEN1KMT2APTGDR2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |