Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 11/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15068050 | 0.82 | EPAS1 (0.60) | EPAS1CA2ALDH1A1 | |
| SCHEMBL23358269 | 0.78 | CNR2 (0.42) | EPAS1IDO1CA2CA1CA9 | |
| SCHEMBL29887062 | 0.74 | EPAS1 (0.51) | EPAS1IDO1CA2CA1CA9 | |
| SCHEMBL2381326 | 0.74 | EPAS1 (0.51) | EPAS1IDO1CA2CA1CA9 | |
| SCHEMBL29555632 | 0.74 | VCAM1 (0.52) | EPAS1IDO1CA2CA1CA9 | |
| SCHEMBL5150927 | 0.74 | VCAM1 (0.52) | EPAS1IDO1CA2CA1CA9 | |
| SCHEMBL21190881 | 0.73 | KMT2A (0.51) | IDO1ALDH1A1 | |
| Ethane SCHEMBL26669304 | 0.73 | CA2 (0.57) | CA2CA1CA9 | |
| SCHEMBL15068035 | 0.72 | CA2 (0.61) | CA2CA1CA9 | |
| SCHEMBL20384341 | 0.72 | EPAS1 (0.43) | EPAS1IDO1CA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110198941-B | Pyrrolopyridine N-oxide derivative and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-09-28 | — | — | CN | disclosed |
| WO-2018137655-A1 | PYRROLO-PYRIDINES N-OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2018-08-02 | — | — | WO | disclosed |