Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TACR2 | P21452 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180870 | 0.72 | KDR (0.43) | — | |
| SCHEMBL15418724 | 0.70 | KDM4E (0.38) | KMT2AGAAPOLBMEN1L3MBTL1 | |
| SCHEMBL7150760 | 0.69 | MEN1 (0.48) | KMT2ASMN1; SMN2TSHRMEN1PKM | |
| SCHEMBL7163542 | 0.68 | CYP1A2 (0.34) | KMT2ASMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL4358646 | 0.68 | CYP1A2 (0.30) | POLB | |
| SCHEMBL506238 | 0.67 | LMNA (0.37) | PKMLMNA | |
| SCHEMBL2040214 | 0.67 | TSPO (0.36) | KMT2ASMN1; SMN2RECQLGAAPPARG | |
| SCHEMBL2040381 | 0.67 | TSPO (0.43) | KMT2ASMN1; SMN2RECQL | |
| SCHEMBL4869728 | 0.66 | EPHX1 (0.44) | KMT2ASMN1; SMN2GAAMEN1L3MBTL1 | |
| SCHEMBL2075972 | 0.66 | EPHX1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512525-B1 | NOVEL ARYLOXYANILIDE IMAGING AGENTS | GE HEALTHCARE LTD (GB) | 2017-06-14 | — | — | EP | disclosed |
| US-9186424-B2 | Aryloxyanilide imaging agents | GE HEALTHCARE LIMITED (GB) | 2015-11-17 | — | — | US | disclosed |
| US-20140288317-A1 | ARYLOXYANILIDE IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2014-09-25 | — | — | US | disclosed |
| US-8771641-B2 | Aryloxyanilide imaging agents | GE HEALTHCARE LIMITED (GB) | 2014-07-08 | — | — | US | disclosed |
| EP-2512525-A1 | ARYLOXYANILIDE IMAGING AGENTS | GE Healthcare UK Limited (GB) | 2012-10-24 | — | — | EP | disclosed |
| US-20120244073-A1 | ARYLOXYANILIDE IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2012-09-27 | — | — | US | disclosed |
| WO-2011073304-A1 | ARYLOXYANILIDE IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120244073-A1 | ARYLOXYANILIDE IMAGING AGENTS | CNR1, GABRA4, GABBR1 | KMT2A 1878/4885SMN1; SMN2 3351/4885RECQL 3857/4885 |
| US-20140288317-A1 | ARYLOXYANILIDE IMAGING AGENTS | GABRA4, GABBR1, CNR1 | KMT2A 1756/4885SMN1; SMN2 3769/4885RECQL 3989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.