SCHEMBL2044444

SCHEMBL2044444

Nc1[nH]cnc2nc(=O)[nH]c1-2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.37
ABL1 P00519 2/20 0.33
RIN1 Q13671 1/20 0.33
CHEK1 O14757 1/20 0.33
AURKA O14965 1/20 0.33
DAPK3 O43293 1/20 0.33
JAK2 O60674 1/20 0.33
NTRK1 P04629 1/20 0.33
CSF1R P07333 1/20 0.33
RET P07949 1/20 0.33
IGF1R P08069 1/20 0.33
PDGFRB P09619 1/20 0.33
PIM1 P11309 1/20 0.33
FGFR1 P11362 1/20 0.33
PRKACA P17612 1/20 0.33
KDR P35968 1/20 0.33
MAP2K2 P36507 1/20 0.33
FLT3 P36888 1/20 0.33
MAPK8 P45983 1/20 0.33
CSNK1A1 P48729 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1749315 0.75 GDA (0.49) PNPTSHRALDH1A1XDHPAX8
Isoguanine SCHEMBL134676 0.65 PNP (0.58) PNPABL1RIN1DPP4ALDH1A1
Isoguanine SCHEMBL3666185 0.65 PNP (0.41) PNPABL1RIN1CHEK1AURKA
Isoguanine SCHEMBL8591972 0.64 PNP (0.56) PNPABL1RIN1DPP4ALDH1A1
Isoguanine SCHEMBL999051 0.61 PNP (0.41) PNPABL1RIN1TSHRDPP4
Isoguanine SCHEMBL134675 0.61 ABL1 (0.53) PNPABL1RIN1FGFR1DPP4
SCHEMBL13863 0.61
SCHEMBL4458196 0.61
Isoguanine SCHEMBL8591970 0.60 ABL1 (0.51) PNPABL1RIN1FGFR1DPP4
SCHEMBL1749456 0.60 KDM4E (0.34) ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11299718-B2 Methods for amplification and sequencing using thermostable TthPrimPol 4basebio Sl (ES) 2022-04-12 US claimed
CN-105283558-B The method for expanding and being sequenced using heat-staple TthPrimPol 西格尼斯生物技术有限责任公司 2019-05-10 CN claimed
EP-2971080-B1 METHODS FOR AMPLIFICATION AND SEQUENCING USING THERMOSTABLE TTHPRIMPOL EXPEDEON S L (ES) 2018-01-03 EP claimed
US-20160040143-A1 METHODS FOR AMPLIFICATION AND SEQUENCING USING THERMOSTABLE TTHPRIMPOL SYGNIS BIOTECH S.L.U. (ES) 2016-02-11 US claimed
CN-105283558-A Methods for amplification and sequencing using thermostable TthPrimPol KOMATSU MFG CO LTD 2016-01-27 CN claimed
EP-2971080-A1 METHODS FOR AMPLIFICATION AND SEQUENCING USING THERMOSTABLE TTHPRIMPOL SYGNIS Biotech S.L.U. (ES) 2016-01-20 EP claimed
WO-2014140309-A1 METHODS FOR AMPLIFICATION AND SEQUENCING USING THERMOSTABLE TTHPRIMPOL SYGNIS BIOTECH S.L.U. (ES) 2014-09-18 WO claimed
US-8546083-B2 Molecular accessibility assay UNIVERSITY OF VERMONT (US) 2013-10-01 US claimed
WO-2011150023-A1 DETECTION OF DAMAGE TO DNA THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2011-12-01 WO claimed
US-20100047791-A1 MOLECULAR ACCESSIBILITY ASSAY NATIONAL INSTITUTES OF HEALTH 2010-02-25 US claimed
WO-2008091541-A1 MOLECULAR ACCESSIBILITY ASSAY UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2008-07-31 WO claimed
EP-4735621-A1 NUCLEIC ACID SYNTHESIS ON REUSABLE SUPPORT DNA Script (FR) 2026-05-06 EP disclosed
EP-4665866-A1 REAGENTS AND METHODS FOR NORMALIZATION Twist Bioscience Corporation (US) 2025-12-24 EP disclosed
US-20250369027-A1 SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS TWIST BIOSCIENCE CORP (US) 2025-12-04 US disclosed
EP-4655411-A2 ENZYMATIC SYNTHESIS OF POLYNUCLEOTIDE PROBES DNA Script (FR) 2025-12-03 EP disclosed
US-20030186344-A1 Detection and quantitation of 8-OH-adenine using monoclonal antibodies CYTOCHEM, INC. 2003-10-02 US disclosed
US-6187551-B1 HYBRIDOMA CULTURE PRODUCT CYTOCHEM, INC. 2001-02-13 US disclosed
WO-1997011371-A1 DETECTION AND QUANTITATION OF 8-OH-ADENINE USING MONOCLONAL ANTIBODIES CYTOCHEM, INC. (US) 1997-03-27 WO disclosed
EP-0719265-A1 NUCLEOSIDE DERIVATIVES, METHODS FOR THE MANUFACTURE THEREOF AND SPECIFIC POLYCLONAL AND MONOCLONAL ANTIBODIES OF SAID DERIVATIVES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1996-07-03 EP disclosed
WO-1995007907-A1 NUCLEOSIDE DERIVATIVES, METHODS FOR THE MANUFACTURE THEREOF AND SPECIFIC POLYCLONAL AND MONOCLONAL ANTIBODIES OF SAID DERIVATIVES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1995-03-23 WO disclosed