Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 1.00 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.94 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.67 |
| ▸ | CBFB | Q13951 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4184260 | 0.97 | DGAT1 (1.00) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL4184180 | 0.88 | DGAT1 (0.78) | NPBWR1DGAT1KCNH2SOAT1 | |
| SCHEMBL30615051 | 0.88 | NPBWR1 (0.78) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL29091542 | 0.88 | NPBWR1 (0.78) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL4191143 | 0.86 | DGAT1 (0.74) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL10381149 | 0.85 | NPBWR1 (1.00) | NPBWR1DGAT1KCNH2SOAT1 | |
| SCHEMBL15245160 | 0.85 | DGAT1 (0.79) | NPBWR1DGAT1KCNH2SOAT1NPC1 | |
| SCHEMBL6325971 | 0.85 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1KDM4E | |
| SCHEMBL529750 | 0.85 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1CBFB | |
| SCHEMBL900794 | 0.85 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2SOAT1CBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | Univerity of Virginia Patent Foundation (US) | 2025-09-02 | — | — | US | disclosed |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | NPBWR1 1227/4885DGAT1 2135/4885KCNH2 61/4885 |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | NPBWR1 1227/4885DGAT1 2135/4885KCNH2 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.