Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC2 | Q92887 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20448813 | 0.93 | ABCC2 (0.43) | ABCC2 | |
| SCHEMBL22198044 | 0.89 | ABCC2 (0.32) | ABCC2 | |
| SCHEMBL20448796 | 0.88 | ABCC2 (0.45) | ABCC2 | |
| SCHEMBL20557005 | 0.87 | ABCC2 (0.44) | ABCC2 | |
| SCHEMBL20448815 | 0.87 | ABCC2 (0.44) | ABCC2 | |
| SCHEMBL20448812 | 0.87 | ABCC2 (0.44) | ABCC2 | |
| SCHEMBL20448805 | 0.87 | ABCC2 (0.43) | ABCC2 | |
| SCHEMBL20448816 | 0.87 | ABCC2 (0.44) | ABCC2 | |
| SCHEMBL20448786 | 0.87 | ABCC2 (0.46) | ABCC2 | |
| SCHEMBL20557306 | 0.86 | ABCC2 (0.42) | ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137574-B | Hydroxyalkyl thiadiazole derivatives | 第一三共株式会社 | 2021-12-28 | — | — | CN | disclosed |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-08-25 | — | — | US | disclosed |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-08-25 | — | — | US | disclosed |
| EP-3356361-B1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2020-07-08 | — | — | EP | disclosed |
| EP-3356361-B1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2020-07-08 | — | — | EP | disclosed |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-02-06 | — | — | US | disclosed |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-02-06 | — | — | US | disclosed |
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-03 | — | — | US | disclosed |
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-03 | — | — | US | disclosed |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-11-15 | — | — | US | disclosed |
| WO-2018169092-A1 | N-PHOSPHONOXYMETHYL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-09-20 | — | — | WO | disclosed |
| EP-3356361-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | TOP1, TOP2B, TOP2A | ABCC2 2306/4885 |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | PHYKPL, SLC34A1, PNKP | ABCC2 2194/4885 |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | PHYKPL, SLC34A1, PNKP | ABCC2 1943/4885 |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | TOP1, TOP2B, TOP2A | ABCC2 2306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.