Antipyrine

Antipyrine

SCHEMBL20452

Cc1cc(=O)n(-c2ccccc2)n1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PTGS1

The experimentally established mechanism targets of Antipyrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 2/20 1.00
ALDH1A1 P00352 4/20 0.49
ALOX15 P16050 2/20 0.49
BCHE P06276 1/20 0.49
PTGS2 P35354 1/20 0.49
LMNA P02545 3/20 0.47
ADORA3 P0DMS8 1/20 0.47
TSHR P16473 3/20 0.46
CYP1A2 P05177 2/20 0.46
THRB P10828 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
GSK3A P49840 1/20 0.45
GSK3B P49841 1/20 0.45
KMT2A Q03164 1/20 0.44
KDM4E B2RXH2 2/20 0.42
CYP2D6 P10635 1/20 0.42
POLB P06746 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Antipyrine SCHEMBL28220175 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL9845605 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL28183108 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL18260589 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL8995343 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL28445203 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL8736656 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL7020007 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL27657914 0.98 NAPRT (0.96) NAPRTALDH1A1ALOX15BCHEPTGS2
Antipyrine SCHEMBL7267167 0.96 NAPRT (0.93) NAPRTALDH1A1ALOX15BCHEPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 87223 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-4747686-A1 ELECTROCHROMIC MULTILAYER ELECTROACTIVE REFLECTIVE MODULE, AND ASSOCIATED SYSTEM AND PRODUCTION METHOD Valeo Vision (FR) 2026-05-27 EP claimed
CN-116390503-B Preparation method and application of double heterojunction passivation perovskite battery interface INNER MONGOLIA ERDOS ELECTRIC POWER METALLURGY GROUP Co.,Ltd. (CN) 2026-05-26 CN claimed
CN-122094940-A Ionizable lipids and uses thereof 2026-05-26 CN claimed
US-20260137650-A1 MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) 11949098 CANADA INC (CA) 2026-05-21 US claimed
WO-2026100708-A1 PHOTOSENSITIVE RESIN LAMINATE, PHOTOSENSITIVE ELEMENT, AND PATTERN FORMING METHOD 旭化成株式会社 2026-05-15 WO claimed
US-20260135149-A1 PREPARATION METHOD OF IONIC LIQUID HON HAI PREC INDUSTRY CO LTD (TW) 2026-05-14 US claimed
EP-4741378-A1 PREPARATION METHOD OF IONIC LIQUID Hon Hai Precision Industry Co., Ltd. (TW) 2026-05-13 EP claimed
EP-4034094-B1 PHOSPHODIESTERASE INHIBITORS AND USE ZENSHINE PHARMACEUTICALS NANJING GROUP CO LTD (CN) 2026-04-15 EP claimed
US-20260083666-A1 METHOD OF TREATING DISEASE CREWS THOMAS M (US) 2026-03-26 US claimed
US-4032348-A METHOD FOR FORMING PHASE HOLOGRAMS FUJI PHOTO FILM CO., LTD. (JA) 1977-06-28 US claimed
US-4030923-A Mixture of binder materials for use in connection with a charge transport layer in a photoconductor INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1977-06-21 US claimed
US-4010271-A NOVEL PYRAZOLINE COMPOUNDS HAVING INSECTICIDAL ACTIVITY U.S. PHILIPS CORPORATION (US) 1977-03-01 US claimed
US-4007256-A PALLADIUM SHELL OIL COMPANY (US) 1977-02-08 US claimed
US-3991073-A Pyrazoline compounds having insecticidal activity U.S. PHILIPS CORPORATION (US) 1976-11-09 US claimed
US-3988430-A ANTIGENS HOFFMANN-LA ROCHE INC. (US) 1976-10-26 US claimed
US-3965255-A DRUG ENCAPSULATED IN OR COATED WITH A SOLVENT MEMBRANE E. E. ELJIM ECOLOGY LTD. (IL) 1976-06-22 US claimed
US-3953380-A FLUORESCENT BRIGHTENER COLGATE-PALMOLIVE COMPANY (US) 1976-04-27 US claimed
US-3952010-A MULTISTAGE, FROM A KETONE AND AN ALDEHYDE, HYDRAZINE AMERICAN CYANAMID COMPANY (US) 1976-04-20 US claimed
US-3948935-A INSECTICIDE, MITICIDE, NEMATOCIDE RHONE-POULENC S.A. (FR) 1976-04-06 US claimed