Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Antipyrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Antipyrine SCHEMBL20452 | 0.98 | NAPRT (1.00) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL8736656 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28445203 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL27657914 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL7020007 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL9845605 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL8995343 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL18260589 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28183108 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL7267167 | 0.94 | NAPRT (0.93) | NAPRTALDH1A1ALOX15BCHEPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108072650-A | The detection kit and its detection method of a kind of residual peroxide | 江苏省药物研究所有限公司 | 2018-05-25 | — | — | CN | disclosed |