Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Antipyrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Antipyrine SCHEMBL2973075 | 0.96 | NAPRT (0.93) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL20452 | 0.96 | NAPRT (1.00) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL9845605 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL18260589 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28220175 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28445203 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL8736656 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL8995343 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL7020007 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28183108 | 0.94 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227525-B2 | Rare earth materials to enhance properties of ceramic particles | BAKER HUGHES, A GE COMPANY, LLC (US) | 2019-03-12 | — | — | US | disclosed |
| WO-2017120275-A1 | RARE EARTH MATERIALS TO ENHANCE PROPERTIES OF CERAMIC PARTICLES | BAKER HUGHES INCORPORATED (US) | 2017-07-13 | — | — | WO | disclosed |
| US-20170190958-A1 | RARE EARTH MATERIALS TO ENHANCE PROPERTIES OF CERAMIC PARTICLES | BAKER HUGHES INCORPORATED (US) | 2017-07-06 | — | — | US | disclosed |
| US-20030118824-A1 | Coated silica particles and method for production thereof | AKZO NOBEL N.V. (NL) | 2003-06-26 | — | — | US | disclosed |