Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Antipyrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Antipyrine SCHEMBL20452 | 0.98 | NAPRT (1.00) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL9845605 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28220175 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28183108 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL8995343 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL28445203 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL8736656 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL18260589 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL27657914 | 0.96 | NAPRT (0.96) | NAPRTALDH1A1ALOX15BCHEPTGS2 | |
| Antipyrine SCHEMBL7267167 | 0.94 | NAPRT (0.93) | NAPRTALDH1A1ALOX15BCHEPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509003-B2 | N-alkylpiperidine derivatives labeled with radioactive iodine; use in single photon emission computed tomography (SPECT) | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2003-01-21 | — | — | US | disclosed |
| EP-0989120-B1 | REAGENTS FOR ASSAYING CENTRAL LOCAL ACETYLCHOLINESTERASE ACTIVITY | DAIICHI PURE CHEMICALS CO LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-20020127180-A1 | Reagents for the determination of cerebral regional acetylcholinesterase activity | DAIICHI PURE CHEMICALS CO., LTD (JP) | 2002-09-12 | — | — | US | disclosed |
| US-6306882-B1 | FLUOROALKYLPIPERIDINE ESTERS COGNITION ACTIVATORS AND ALZHEIMER'S | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2001-10-23 | — | — | US | disclosed |
| EP-0989120-A1 | REAGENTS FOR ASSAYING CENTRAL LOCAL ACETYLCHOLINESTERASE ACTIVITY | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2000-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020127180-A1 | Reagents for the determination of cerebral regional acetylcholinesterase activity | ACHE, BCHE, CHAT | NAPRT 2206/4885ALDH1A1 61/4885ALOX15 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.