Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL1409802 | 0.95 | ALDH1A1 (0.51) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL30856538 | 0.88 | L3MBTL1 (0.54) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL30856524 | 0.88 | L3MBTL1 (0.54) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL3969873 | 0.88 | L3MBTL1 (0.54) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL3965126 | 0.88 | L3MBTL1 (0.54) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| Succinic Acid SCHEMBL2784463 | 0.87 | FOLH1 (0.46) | ALDH1A1TSHRFFAR1FFAR4 | |
| Acetic Acid SCHEMBL21328386 | 0.87 | L3MBTL1 (0.58) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL22367410 | 0.87 | SMN1; SMN2 (0.53) | ALDH1A1TSHRMAPK1FFAR1FFAR4 | |
| SCHEMBL25801992 | 0.85 | MAPT (0.53) | L3MBTL1TSHRMAPK1FFAR1 | |
| SCHEMBL25616458 | 0.85 | L3MBTL1 (0.50) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2202267-B1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEM IND (JP) | 2011-12-07 | — | — | EP | claimed |
| EP-2202267-A1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-06-30 | — | — | EP | claimed |
| CN-101495569-B | Resin composition, method for producing same, and molded article | TEIJIN LTD | 2012-05-30 | — | — | CN | disclosed |
| EP-2202267-B1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEM IND (JP) | 2011-12-07 | — | — | EP | disclosed |
| US-20110160364-A1 | RESIN COMPOSITION, MANUFACTURING METHOD THEREOF, AND MOLDED ARTICLE | TEIJIN LIMITED (JP) | 2011-06-30 | — | — | US | disclosed |
| CN-101939380-A | Resin composition and molded article | TEIJIN LTD | 2011-01-05 | — | — | CN | disclosed |
| US-20100324220-A1 | RESIN COMPOSITION AND MOLDED ARTICLE | TEIJIN LIMITED (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2256165-A1 | RESIN COMPOSITION AND MOLDED ARTICLE | Teijin Limited (JP) | 2010-12-01 | — | — | EP | disclosed |
| US-7803298-B2 | Molding material, molded part, and method for manufacturing them | SUMITOMO ELECTRIC FINE POLYMER, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-2202267-A1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-06-30 | — | — | EP | disclosed |
| CN-101495569-A | Resin composition, method for producing same, and molded article | TEIJIN LTD (JP) | 2009-07-29 | — | — | CN | disclosed |
| EP-2053091-A1 | RESIN COMPOSITION, METHOD FOR PRODUCING THE SAME AND MOLDED ARTICLE | TEIJIN LIMITED (JP) | 2009-04-29 | — | — | EP | disclosed |
| US-20090030160-A1 | Polylactic Acid Complex and Production Method Thereof | SUMITOMO ELECTRIC FINE POLYMER INC. (JP) | 2009-01-29 | — | — | US | disclosed |
| CN-101146851-A | Method for preparing polylactic acid composite and polylactic acid composite produced by the method | SUMITOMO ELEC FINE POLYMER INC (JP) | 2008-03-19 | — | — | CN | disclosed |
| CN-101125929-A | Molding material, molded product, and method for manufacturing them | SUMITOMO ELEC FINE POLYMER INC (JP) | 2008-02-20 | — | — | CN | disclosed |
| US-20080036119-A1 | Molding material, molded part, and method for manufacturing them | SUMITOMO ELECTRIC FINE POLYMER, INC. | 2008-02-14 | — | — | US | disclosed |
| US-7166654-B2 | Ester compound, plasticizer for biodegradable aliphatic polyester resin, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-01-23 | — | — | US | disclosed |
| US-20050228092-A1 | Ester compound, plasticizer for bioegradable aliphatic polyester resin, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2005-10-13 | — | — | US | disclosed |