Sugi Predict

Sugi Predict / Compounds / SCHEMBL2045474

SCHEMBL2045474

SCHEMBL2045474

CO/N=C(C(=N/OC)/c1ccccc1)\c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.44
▸ LMNA P02545 2/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ TYMP P19971 1/20 0.42
▸ GAA P10253 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ CES1 P23141 4/20 0.39
▸ CES2 O00748 3/20 0.39
▸ ATM Q13315 1/20 0.38
▸ MAPT P10636 2/20 0.38
▸ F2 P00734 1/20 0.37
▸ CDK5 Q00535 2/20 0.37
▸ CDK5R1 Q15078 2/20 0.37
▸ PKM P14618 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2045476 1.00 TSHR (0.44) TSHRLMNAMAPK1HTTL3MBTL1
SCHEMBL6292705 0.91 SMN1; SMN2 (0.50) TSHRLMNAMAPK1HTTL3MBTL1
SCHEMBL3689392 0.87 TSHR (0.48) TSHRLMNAL3MBTL1TYMPGAA
SCHEMBL3958996 0.87 TSHR (0.48) TSHRLMNAL3MBTL1TYMPGAA
SCHEMBL8007984 0.87 TSHR (0.48) TSHRLMNAL3MBTL1TYMPGAA
SCHEMBL3689389 0.85 TSHR (0.47) TSHRLMNAMAPK1L3MBTL1TYMP
SCHEMBL7651351 0.85 CES1 (0.48) TSHRLMNAMAPK1HTTL3MBTL1
SCHEMBL7805644 0.85 CES1 (0.48) TSHRLMNAMAPK1HTTL3MBTL1
SCHEMBL3689388 0.85 TSHR (0.47) TSHRLMNAMAPK1L3MBTL1TYMP
SCHEMBL9900446 0.85 CES2 (0.50) TSHRLMNAHTTTYMPGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 — — US claimed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 — — EP claimed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 — — US claimed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 — — US disclosed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 — — EP disclosed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 — — US disclosed
US-6858745-B2 Alkyl cobalt (III) dioximates and process for forming the same E. I. DU PONT DE NEMOURS AND COMPANY (US) 2005-02-22 — — US disclosed
US-6740618-B2 REACTIN A GLYOXIME, A COBALT SALT, AN UNSATURATED COMPOUND SUCH AS AN ALKYL ACRYLATE, AND A LEWIS BASE IN H2; USE AS A POLYMERIZATION CATALYST, ESPECIALLY IN POLYMERIZING METHYL METHACRYLATE E. I. DU PONT DE NEMOURS AND COMPANY 2004-05-25 — — US disclosed
US-6713427-B2 TREATING A MIXTURE OF A COBALT (II) SALT, A DIOXIME OF THE FORMULA R1-C( HORIZONTAL-LINE NOH)-C( HORIZONTAL-LINE NOH)-R2, AN ACRYLIC ESTER, A LEWIS BASE WITH MOLECULAR HYDROGEN TO FORM A COBALT DIOXIMATE COMPLEX E. I. DU PONT DE NEMOURS AND COMPANY 2004-03-30 — — US disclosed
US-20030149275-A1 Alkyl cobalt (III) dioximates and process for forming the same AXALTA COATING SYSTEMS IP CO. LLC (FORMERLY KNOWN AS U.S. COATINGS IP CO. LLC) 2003-08-07 — — US disclosed
US-20030135054-A1 Alkyl cobalt(III) dioximates and process for forming the same GRIDNEV ALEXEI A (US) 2003-07-17 — — US disclosed
US-20030125564-A1 Alkyl cobalt (III) dioximates and process for forming the same AXALTA COATING SYSTEMS IP CO. LLC (FORMERLY KNOWN AS U.S. COATINGS IP CO. LLC) 2003-07-03 — — US disclosed
US-6559327-B2 By reacting a cobalt salt, a dioxime such as diphenylglyoxime, a lewis base such as 1,2-dimethylimidazole, and an olefinic compound such as methyl acrylate, and treating with hydrogen; high yield, purity E. I. DU PONT DE NEMOURS AND COMPANY 2003-05-06 — — US disclosed
EP-1221447-A2 Alkyl Cobalt (III) Dioximates and process for forming the same E. I. du Pont de Nemours and Company (US) 2002-07-10 — — EP disclosed
US-20020087006-A1 Alkyl cobalt (III) dioximates and process for forming the same AXALTA COATING SYSTEMS IP CO. LLC (FORMERLY KNOWN AS U.S. COATINGS IP CO. LLC) 2002-07-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030149275-A1 Alkyl cobalt (III) dioximates and process for forming the same CCR3, CBR3, CCR6 TSHR 480/4885LMNA 4147/4885MAPK1 3103/4885
US-20030125564-A1 Alkyl cobalt (III) dioximates and process for forming the same CCR3, CBR3, CCR6 TSHR 468/4885LMNA 4165/4885MAPK1 3064/4885
US-20020087006-A1 Alkyl cobalt (III) dioximates and process for forming the same CCR3, CBR3, CCR6 TSHR 468/4885LMNA 4165/4885MAPK1 3064/4885
US-20030135054-A1 Alkyl cobalt(III) dioximates and process for forming the same CCR3, CBR3, CCR6 TSHR 468/4885LMNA 4165/4885MAPK1 3064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.