Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1426593 | 0.87 | CYP2D6 (0.84) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| SCHEMBL20556630 | 0.86 | CYP2D6 (0.59) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| Hydrochloric Acid SCHEMBL20455783 | 0.86 | CYP2D6 (0.61) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| Hydrochloric Acid SCHEMBL3013775 | 0.85 | CYP2D6 (0.82) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| SCHEMBL19850536 | 0.85 | CYP3A4 (0.85) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| SCHEMBL22248489 | 0.83 | CYP2D6 (0.59) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| SCHEMBL20558033 | 0.82 | CYP2D6 (0.51) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| Hydrochloric Acid SCHEMBL20455796 | 0.82 | CYP2D6 (0.57) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| Hydrochloric Acid SCHEMBL20455756 | 0.80 | CYP3A4 (0.57) | CYP2D6CYP3A4TSHRCYP1A2KDM1A | |
| Hydrochloric Acid SCHEMBL20455757 | 0.79 | PDCD1LG2 (0.51) | CYP2D6CYP3A4TSHRCYP1A2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048267-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-13 | — | — | US | disclosed |
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2019-08-20 | — | — | US | disclosed |
| WO-2018141984-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2018-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048267-A1 | OGA INHIBITOR COMPOUNDS | OGA, OGT, GRN | CYP2D6 4092/4885CYP3A4 4278/4885TSHR 4632/4885 |
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | FAAH, FAAH2, MGLL | CYP2D6 114/4885CYP3A4 193/4885TSHR 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.