Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000805 | 0.84 | MAPT (0.58) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL17669252 | 0.82 | MAPT (0.71) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL15801114 | 0.82 | MAPT (0.71) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL9531913 | 0.79 | NPC1 (0.68) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL20456244 | 0.79 | CYP2C9 (0.46) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL20456231 | 0.77 | L3MBTL1 (0.51) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL336009 | 0.75 | NPC1 (0.65) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL909633 | 0.75 | MAPT (0.62) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL15156349 | 0.75 | MAPT (0.62) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL6601289 | 0.74 | CHKA (0.50) | MAPTSMN1; SMN2KDM4ENAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144869-A1 | COMPOSITONS AND METHODS FOR MODULATING UBA5 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018144871-A1 | COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |