Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 15/20 | 0.73 |
| ▸ | PKLR | P30613 | 8/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19871299 | 1.00 | PKM (0.73) | PKMPKLRALDH1A1POLBHTT | |
| SCHEMBL19871301 | 0.85 | PKM (0.79) | PKMPKLRALDH1A1POLBTDP1 | |
| SCHEMBL2239830 | 0.85 | PKM (1.00) | PKMPKLRPOLBTDP1 | |
| SCHEMBL17800944 | 0.84 | PKM (0.74) | PKMPKLRTDP1 | |
| SCHEMBL12354639 | 0.84 | PKM (1.00) | PKMPKLRTDP1 | |
| SCHEMBL17808925 | 0.84 | PKM (1.00) | PKMPKLRALDH1A1HTT | |
| SCHEMBL29945828 | 0.84 | PKM (1.00) | PKMPKLRALDH1A1HTT | |
| SCHEMBL1725495 | 0.84 | PKM (1.00) | PKMPKLRALDH1A1HTT | |
| SCHEMBL19871300 | 0.84 | PKM (1.00) | PKMPKLRALDH1A1HTT | |
| SCHEMBL10724066 | 0.83 | PKM (0.88) | PKMALDH1A1POLBHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10039844-B2 | Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2 | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10039844-B2 | Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2 | PDK2, PDK3, PDK1 | PKM 5/4885PKLR 19/4885ALDH1A1 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.