Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 4/20 | 0.39 |
| ▸ | MMP8 | P22894 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2050703 | 1.00 | ITGB3 (0.46) | ITGB3ITGA2BITGAVBRD4MIF | |
| SCHEMBL2786598 | 0.86 | ITGB3 (0.52) | ITGB3ITGA2BITGAVMMP8MMP3 | |
| SCHEMBL2786534 | 0.86 | ITGB3 (0.52) | ITGB3ITGA2BITGAVMMP8MMP3 | |
| SCHEMBL12922971 | 0.86 | MMP8 (0.38) | ITGB3ITGA2BITGAVMIFMMP8 | |
| SCHEMBL12922965 | 0.86 | MMP8 (0.38) | ITGB3ITGA2BITGAVMIFMMP8 | |
| SCHEMBL4671293 | 0.82 | ITGB3 (0.50) | ITGB3ITGA2BITGAVMIFMMP8 | |
| SCHEMBL13688296 | 0.82 | ITGB3 (0.50) | ITGB3ITGA2BITGAVMIFMMP8 | |
| SCHEMBL12948918 | 0.82 | ITGB3 (0.50) | ITGB3ITGA2BITGAVMIFMMP8 | |
| SCHEMBL981045 | 0.82 | ITGB3 (0.50) | ITGB3ITGA2BITGAVMIFMMP8 | |
| SCHEMBL23082999 | 0.81 | OPRM1 (0.36) | ITGB3ITGA2BITGAVMIFMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2329821-A1 | Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema | GlaxoSmithKline LLC (US) | 2011-06-08 | — | — | EP | disclosed |