Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 3/20 | 0.60 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | IDH2 | P48735 | 3/20 | 0.49 |
| ▸ | CCR9 | P51686 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17506545 | 0.75 | CKS1B (1.00) | CKS1BSKP2TSHRIDH2KMT2A | |
| SCHEMBL4491744 | 0.74 | CKS1B (0.62) | CKS1BSKP2TSHRIDH2CCR9 | |
| SCHEMBL1872226 | 0.70 | CKS1B (0.47) | CKS1BSKP2TSHRIDH2KMT2A | |
| SCHEMBL17506544 | 0.66 | CKS1B (1.00) | CKS1BSKP2SLC40A1CLK1 | |
| SCHEMBL15702482 | 0.66 | IDH2 (1.00) | IDH2 | |
| SCHEMBL7578819 | 0.65 | MEN1 (0.63) | TSHRKMT2ASLC40A1CLK1ACLY | |
| SCHEMBL7592771 | 0.65 | MEN1 (0.74) | CKS1BSKP2TSHRKMT2ASLC40A1 | |
| SCHEMBL10581966 | 0.64 | CCR2 (0.62) | CKS1BSKP2TSHRKMT2ASLC40A1 | |
| SCHEMBL25140639 | 0.64 | USP2 (0.66) | CKS1BSKP2TSHRKMT2AACLY | |
| SCHEMBL19848269 | 0.64 | KMT2A (0.60) | CKS1BSKP2TSHRCCR9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040766-B2 | Ubiquitination inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2018-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040766-B2 | Ubiquitination inhibitors | MDM2, RBX1, NEDD4 | CKS1B 206/4885SKP2 51/4885TSHR 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.