Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872327 | 0.87 | HRH3 (0.38) | GAALMNAPOLBRECQLALDH1A1 | |
| SCHEMBL6496552 | 0.87 | HRH3 (0.36) | GAALMNAPOLBCHRM2RECQL | |
| SCHEMBL21160967 | 0.87 | HRH3 (0.36) | GAALMNAPOLBCHRM2RECQL | |
| SCHEMBL633803 | 0.87 | HRH3 (0.36) | GAALMNAPOLBCHRM2RECQL | |
| SCHEMBL18768680 | 0.87 | HRH3 (0.36) | GAALMNAPOLBCHRM2RECQL | |
| SCHEMBL17469149 | 0.85 | HRH3 (0.35) | GAALMNAPOLBACHECHRM2 | |
| SCHEMBL16627520 | 0.85 | HRH3 (0.35) | GAALMNAPOLBACHECHRM2 | |
| SCHEMBL19649547 | 0.85 | RECQL (0.38) | GAALMNAPOLBACHECHRM2 | |
| SCHEMBL16627509 | 0.85 | RECQL (0.38) | GAALMNAPOLBACHECHRM2 | |
| SCHEMBL16627498 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443107-B1 | AZETIDINE 2 -CARBOXAMIDE DERIVATIVES WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INT (DE) | 2018-08-08 | — | — | EP | disclosed |