Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30826948 | 0.84 | NNMT (0.53) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL31747260 | 0.76 | NNMT (0.45) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL2691837 | 0.76 | NNMT (0.52) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL29537517 | 0.76 | NNMT (0.52) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL31747380 | 0.75 | NNMT (0.44) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL27779102 | 0.73 | NNMT (0.57) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL2937228 | 0.73 | NNMT (0.57) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL30557594 | 0.73 | NNMT (0.57) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL5234177 | 0.73 | NNMT (0.57) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 | |
| SCHEMBL9786932 | 0.72 | NNMT (0.55) | NNMTSMN1; SMN2KDM4EL3MBTL1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144649-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas, Inc. (US) | 2018-08-09 | — | — | WO | disclosed |