Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19072733 | 0.79 | GRM5 (0.41) | ASIC3TGFBR1 | |
| SCHEMBL27039915 | 0.78 | FEN1 (0.42) | ASIC3FEN1ALOX5APBACE1MAP4K4 | |
| SCHEMBL20456721 | 0.77 | TGFBR1 (0.36) | TGFBR1TGFBR2 | |
| SCHEMBL31484870 | 0.76 | CCR1 (0.48) | TGFBR1KDM1AMAPK10 | |
| SCHEMBL810938 | 0.76 | CCR1 (0.48) | TGFBR1KDM1AMAPK10 | |
| SCHEMBL5934924 | 0.74 | ASIC3 (0.59) | ASIC3ALDH1A1TGFBR1MAPT | |
| SCHEMBL24018528 | 0.73 | ALOX5AP (0.48) | FEN1ALOX5APBACE1MAPT | |
| SCHEMBL31168033 | 0.73 | IDO1 (0.39) | ADORA2BTGFBR1MAPTMAPK14MAPK11 | |
| SCHEMBL20468885 | 0.73 | GRM5 (0.43) | FEN1ALOX5APTGFBR1KDM1A | |
| SCHEMBL28731089 | 0.72 | ASIC3 (0.57) | ASIC3ALDH1A1TGFBR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3577110-B1 | 8-OXETAN-3-YL-3,8-DIAZABICYCLO[3.2.1]OCTAN-3-YL SUBSTITUTED COMPOUNDS AS HIV INHIBITORS | GILEAD SCIENCES INC (US) | 2021-04-21 | — | — | EP | disclosed |
| WO-2018145021-A1 | ATAZANAVIR (ATV) ANALOGUES FOR TREATING HIV INFECTIONS | GILEAD SCIENCES, INC. (US) | 2018-08-09 | — | — | WO | disclosed |