Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20469357 | 1.00 | CYP3A4 (0.38) | CYP3A4ALDH1A1HTTHSD11B1EPHX2 | |
| SCHEMBL13223564 | 1.00 | CYP3A4 (0.38) | CYP3A4ALDH1A1HTTHSD11B1EPHX2 | |
| SCHEMBL22991226 | 0.89 | RIPK1 (0.38) | CYP3A4ALDH1A1HTTHSD11B1EPHX2 | |
| SCHEMBL13223563 | 0.88 | CYP3A4 (0.43) | CYP3A4ALDH1A1HTTHSD11B1EPHX2 | |
| SCHEMBL17177141 | 0.83 | SPR (0.38) | CYP3A4ALDH1A1HTTHSD11B1EPHX2 | |
| SCHEMBL15617801 | 0.83 | MEN1 (0.33) | CYP3A4ALDH1A1HTTEPHX2MEN1 | |
| SCHEMBL12661420 | 0.82 | HSD11B1 (0.35) | CYP3A4HSD11B1EPHX2CNR2 | |
| SCHEMBL27906724 | 0.79 | HRH3 (0.35) | ALDH1A1MEN1KMT2AGRM3CNR2 | |
| SCHEMBL15490628 | 0.78 | SPR (0.42) | CYP3A4ALDH1A1HTTHSD11B1EPHX2 | |
| SCHEMBL18701846 | 0.78 | HSD11B1 (0.50) | CYP3A4ALDH1A1HTTHSD11B1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2018-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | BACE1, BACE2, APP | CYP3A4 677/4885ALDH1A1 1466/4885HTT 2229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.