Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | UTRN | P46939 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20469712 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL23542086 | 0.87 | SMN1; SMN2 (0.48) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL20469792 | 0.86 | CETP (0.40) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL20469713 | 0.86 | CETP (0.40) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL20469752 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL29572967 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL20469761 | 0.85 | CETP (0.42) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL20469753 | 0.85 | CETP (0.42) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL23542058 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL20469796 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040963-B2 | Piperazine derivatives for influenza virus inhibitions | JANSSEN VACCINES & PREVENTION B.V. (NL) | 2021-06-22 | — | — | US | disclosed |
| WO-2018141854-A1 | PIPERAZINE DERIVATIVES FOR INFLUENZA VIRUS INHIBITION | JANSSEN VACCINES & PREVENTION B.V. (NL) | 2018-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040963-B2 | Piperazine derivatives for influenza virus inhibitions | HAVCR2, BAZ2A, MAVS | ALDH1A1 631/4885KDM4E 1451/4885SMN1; SMN2 4850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.