Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21166757 | 0.84 | KDM4E (0.61) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL20470550 | 0.83 | RAB9A (0.42) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL21166650 | 0.83 | MAPT (0.57) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL21656987 | 0.82 | PARP10 (0.50) | MAPTRAB9ANPC1ALDH1A1POLB | |
| SCHEMBL23228713 | 0.78 | LMNA (0.43) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL21656877 | 0.77 | HPGD (0.55) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL1857763 | 0.75 | MAPT (0.73) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL15054796 | 0.75 | MAPT (1.00) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL13019390 | 0.74 | MAPT (0.53) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL7607195 | 0.73 | MAPT (0.70) | MAPTRAB9ANPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10274481-B2 | Method for identifying modulators of notch signaling | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2019-04-30 | — | — | US | disclosed |
| US-20180224429-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2018-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10274481-B2 | Method for identifying modulators of notch signaling | NOTCH3, NOTCH1, NOTCH4 | MAPT 3343/4885RAB9A 3388/4885NPC1 1941/4885 |
| US-20180224429-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | NOTCH3, NOTCH1, NOTCH4 | MAPT 3407/4885RAB9A 3103/4885NPC1 2594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.