Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29786531 | 1.00 | TACR1 (0.39) | TACR1CARM1PRMT1KCNH2SLC6A2 | |
| SCHEMBL22392098 | 0.81 | RIPK1 (0.54) | TACR1KCNH2SLC6A2SLC6A4TSHR | |
| SCHEMBL22957817 | 0.81 | TACR1 (0.45) | TACR1KCNH2SLC6A2SLC6A4MEN1 | |
| SCHEMBL855754 | 0.81 | IRAK4 (0.47) | TACR1KCNH2SLC6A2SLC6A4TSHR | |
| SCHEMBL29786441 | 0.81 | IRAK4 (0.47) | TACR1KCNH2SLC6A2SLC6A4TSHR | |
| SCHEMBL24180112 | 0.78 | ADRA2B (0.44) | HPGDADRA2AADRA2BADRA2CIDO1 | |
| SCHEMBL24224738 | 0.76 | HPGD (0.57) | SLC6A2SLC6A4TSHRHPGDADRA2A | |
| SCHEMBL23761306 | 0.75 | ADRA2A (0.44) | HPGDHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL18706901 | 0.73 | ADRA2A (0.43) | TSHRHPGDHTR1AADRA2AADRA2B | |
| SCHEMBL7013166 | 0.73 | MCHR1 (0.46) | HTR1AADRA2AADRA2BADRA2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018148626-A1 | AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-08-16 | — | — | WO | disclosed |