Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.44 |
| ▸ | HPGDS | O60760 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17967333 | 0.90 | SLC16A3 (0.48) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL635539 | 0.78 | PTGS1 (0.52) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL24373427 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1NPC1RAB9APLA2G2A | |
| SCHEMBL7147155 | 0.75 | ALDH1A1 (0.68) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL26882759 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10CYP11B1CYP11B2 | |
| SCHEMBL9952903 | 0.73 | KDM4E (0.54) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL21464329 | 0.73 | KDM4E (0.51) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL19478133 | 0.71 | DYRK1A (0.52) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL1574317 | 0.70 | KDM4E (0.80) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL4741387 | 0.70 | GPBAR1 (0.57) | KDM4ENPC1PLA2G2AHPGDSCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227355-B2 | Quinoline derivatives and preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-03-12 | — | — | US | disclosed |
| US-20180237448-A1 | NOVEL QUINOLINE DERIVATIVES AND PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180237448-A1 | NOVEL QUINOLINE DERIVATIVES AND PREPARATION THEREOF | ABL1, FLT3, MAP3K7 | KDM4E 892/4885ALDH1A1 1992/4885MAPT 2812/4885 |
| US-10227355-B2 | Quinoline derivatives and preparation thereof | ABL1, FLT3, MAP3K7 | KDM4E 939/4885ALDH1A1 2096/4885MAPT 2415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.