Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17967333 | 0.89 | SLC16A3 (0.48) | PTGS1AKR1C3AKR1C2SLC16A3ALDH1A1 | |
| SCHEMBL7064360 | 0.80 | KDM4E (0.52) | AKR1C3AKR1C2SLC16A3ALDH1A1KDM4E | |
| SCHEMBL28532626 | 0.80 | KDM4E (0.52) | SLC16A3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL31055812 | 0.80 | KDM4E (0.52) | AKR1C3AKR1C2SLC16A3ALDH1A1KDM4E | |
| SCHEMBL2945200 | 0.80 | ALDH1A1 (0.67) | SLC16A3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL20474255 | 0.78 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL621720 | 0.78 | KDM4E (0.58) | SLC16A3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4489484 | 0.78 | TDP1 (0.50) | PTGS1AKR1C3AKR1C2SLC16A3ALDH1A1 | |
| SCHEMBL4487533 | 0.77 | KDM4E (0.45) | PTGS1AKR1C3AKR1C2SLC16A3ALDH1A1 | |
| SCHEMBL4495043 | 0.76 | SLC16A3 (0.46) | SLC16A3ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507778-B1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | UNIV TROBE (AU) | 2012-02-22 | — | — | EP | disclosed |
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | BAGULEY BRUCE CHARLES | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | MKI67, MCL1, CCNI | PTGS1 616/4885AKR1C3 1813/4885AKR1C2 1585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.