Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 3/20 | 0.51 |
| ▸ | KDM4B | O94953 | 2/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20476591 | 0.89 | KDM5C (0.51) | KDM5CKDM4BKDM5BPIM1CCNT1 | |
| SCHEMBL20476554 | 0.87 | P4HA1 (0.57) | KDM5CKDM4BKDM5BHDAC6KDM4C | |
| SCHEMBL20476711 | 0.83 | KDM4E (0.58) | KDM5CKDM5BCDK8HDAC6KDM4C | |
| SCHEMBL7038517 | 0.78 | KDM5C (0.69) | KDM5CKDM4BKDM5BPIM1KDM4C | |
| SCHEMBL1207795 | 0.74 | HDAC6 (0.48) | CCNT1CCND1CCNCCDK8CDK7 | |
| Hydrochloric Acid SCHEMBL3831639 | 0.73 | HDAC6 (0.47) | CCNT1CCND1CCNCCDK8CDK7 | |
| SCHEMBL29018616 | 0.72 | HDAC6 (0.39) | HDAC6RIPK1MAOBMAPK1GRM4 | |
| SCHEMBL18231524 | 0.72 | KDM5C (0.66) | KDM5CKDM4BKDM5BKDM4CKDM4A | |
| SCHEMBL29540009 | 0.72 | F2 (0.68) | KDM4EMAOBAR | |
| SCHEMBL27522161 | 0.72 | F2 (0.68) | KDM4EMAOBAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018149986-A1 | 2-(BICYCLO-HETEROARYL)-ISONICOTINIC DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2018-08-23 | — | — | WO | disclosed |