Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2023788 | 0.93 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2025839 | 0.83 | PDE4B (0.53) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL23040449 | 0.82 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL31455322 | 0.80 | LMNA (0.51) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL1990033 | 0.80 | NR1H2 (0.44) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL1990031 | 0.80 | NR1H2 (0.44) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL30376364 | 0.78 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL1990570 | 0.77 | USP30 (0.40) | RAB9ADRD3PDK1MEN1KMT2A | |
| SCHEMBL16463868 | 0.75 | GRIN2B (0.46) | LMNASMN1; SMN2POLBPDE4BDRD3 | |
| SCHEMBL34474080 | 0.74 | POLB (0.45) | LMNATSHRSMN1; SMN2POLBPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516392-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076678-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-30 | — | — | WO | disclosed |