Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2025839 | 0.94 | PDE4B (0.53) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL31455322 | 0.89 | LMNA (0.51) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL30376364 | 0.86 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2047643 | 0.82 | LMNA (0.45) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL4709679 | 0.81 | PRMT5 (0.64) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22659030 | 0.80 | PDE4B (0.53) | LMNAPDE4DPDE4BPRMT5WDR77 | |
| SCHEMBL15531501 | 0.80 | LMNA (0.50) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL31421713 | 0.80 | LMNA (0.47) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2023788 | 0.79 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL1988650 | 0.78 | PDE4B (0.52) | PDE4BPRMT5ALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697636-B2 | Substituted benzamides | HOFFMANN-LA ROCHE INC. (US) | 2023-07-11 | — | — | US | disclosed |
| US-20210061760-A1 | SUBSTITUTED BENZAMIDES | HOFFMANN LA ROCHE (US) | 2021-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061760-A1 | SUBSTITUTED BENZAMIDES | TAAR1, TAAR5, NPY1R | LMNA 3001/4885CYP1A2 164/4885CYP3A4 510/4885 |
| US-11697636-B2 | Substituted benzamides | TAAR1, TAAR5, NPY1R | LMNA 3001/4885CYP1A2 164/4885CYP3A4 510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.