Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23040449 | 0.94 | LMNA (0.49) | PDE4BPRMT5WDR77LMNACYP1A2 | |
| SCHEMBL30376364 | 0.93 | LMNA (0.49) | PDE4BPRMT5WDR77LMNACYP1A2 | |
| SCHEMBL31455322 | 0.90 | LMNA (0.51) | PDE4BPRMT5WDR77LMNACYP1A2 | |
| SCHEMBL4709679 | 0.88 | PRMT5 (0.64) | PDE4BPRMT5WDR77LMNACYP1A2 | |
| SCHEMBL22659030 | 0.85 | PDE4B (0.53) | PDE4BPRMT5WDR77LMNAPDE4D | |
| SCHEMBL15531501 | 0.83 | LMNA (0.50) | PDE4BLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2047643 | 0.83 | LMNA (0.45) | PDE4BPRMT5WDR77LMNACYP1A2 | |
| SCHEMBL2023788 | 0.82 | LMNA (0.49) | PDE4BPRMT5WDR77LMNACYP1A2 | |
| SCHEMBL29742014 | 0.80 | TRPC6 (0.50) | PDE4BLMNARAB9AALDH1A1NPC1 | |
| SCHEMBL15379831 | 0.80 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516392-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076678-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-30 | — | — | WO | disclosed |