Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 5/20 | 0.46 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20476734 | 0.76 | KDM5A (0.54) | ICMTKDM4EMAPTHRH3 | |
| SCHEMBL3351981 | 0.76 | ICMT (0.55) | ICMTCYP2A13KDM4EHIF1ACNR2 | |
| SCHEMBL20476694 | 0.74 | JMJD6 (0.43) | ICMTKDM4EMTNR1BCNR1RAB9A | |
| SCHEMBL20476439 | 0.73 | ICMT (0.38) | ICMTCNR2CNR1 | |
| SCHEMBL21052367 | 0.72 | CNR1 (0.33) | CNR2CNR1RAB9A | |
| SCHEMBL3357604 | 0.71 | CTSB (0.56) | ICMTCNR2CNR1MAPTHTR6 | |
| SCHEMBL31637794 | 0.71 | CYP2C9 (0.51) | CYP2A13KDM4ECNR2CNR1RAB9A | |
| SCHEMBL5962241 | 0.71 | ALDH1A1 (0.52) | KDM4E | |
| SCHEMBL21052313 | 0.70 | HDAC6 (0.48) | ICMT | |
| SCHEMBL31638028 | 0.69 | HTT (0.52) | CYP2A13KDM4EHIF1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018149986-A1 | 2-(BICYCLO-HETEROARYL)-ISONICOTINIC DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2018-08-23 | — | — | WO | disclosed |